To foster integrity and minimize research misconduct and questionable research practices, RPOs need to nurture a supportive environment. Competition, publication pressure, detrimental power imbalances, and conflicts must be explicitly addressed and adequately handled. Fair, transparent, and responsible policies for assessing, appointing, and promoting researchers must be in place. Diversity and inclusion must be actively promoted. Collegiality, openness, reflection, and responsibility are vital elements of a working environment where the risk of major and minor breaches of good research practices is minimized.